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florfenicol, cas 73231-34-2
What is Florfenicol? Florfenicol is a fluorinated synthetic analog of thiamphenicol. It was successfully developed in late 1980s. It is a broad-spectrum antibacterial classified in chloramphenicol. Florfenicol was marketed first in Japan in 1990. In 1993, Florfenicol was approved by Norway for using in the treatment of dothienesis in trout. In 1995, it was approved by France, England, Austria, Mexico, and Spain for using in the treatment of bovine respiratory diseases. In Japan and Mexico, Florfenicol is approved as feed additive for pigs, preventing and treating swine bacteriosis. It has also been approved in China. Pharmacology of Florfenicol Due to its liposolubility, Florfenicol can diffuse into the cells of bacteria. It works on the 50s subunit of the 70s ribosome and restrain the extension of transpeptidase and thus the formation of peptide chain. The synthesis of protein is therefore prevented. The antibacterial spectrum of Florfenicol is very broad. It is particularly effective against Grams positive and negative bacteria and mycoplasma. The bacteria that are sensitive to Florfenicol include hemophilus, Shigella dysenteriae, salmonella, colibacillus, pneumococcus, Bacillus influenzae, streptococcus, Staphylococcus aureus, chlamydia, Leptospira, and Rickett's organism, etc. in swine and cattle. Oral Florfenicol is fast to absorb. It distributes broadly in the body, with long half-life period, high blood concentration, and lasts long in blood.

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