new research, scientists found 19,000 protein producing genes in humans

19,000 protein producing genes in humans, finds new study

11:50 AM, 7th July 2014
19,000 protein producing genes in humans
The study says that almost all of these genes have ancestors prior to the appearance of primates 50 million years ago.

LONDON, UK: In a new research, scientists have found the number of protein generating genes in humans to be 19,000 - 1,700 fewer than the most recent annotation and well below the initial estimations of 100,000 genes. The study says that almost all of these genes have ancestors prior to the appearance of primates 50 million years ago.

“I call it the shrinking human genome. The coding part of the genome (which produces proteins) is constantly moving. No one could have imagined a few years ago that such a small number of genes could make something so complex,” explained Alfonso Valencia, Vice Director, Spanish National Cancer Research Centre (CNIO).

In order to determine a map of human proteins, the researchers integrated data from seven large-scale mass spectrometry studies - from more than 50 human tissues – “in order to verify which genes really do produce proteins.”

They analysed thousands of genes that were annotated in the human genome, but that did not appear in the proteomics analysis - the most powerful tool to detect protein molecules.

“1,700 of the genes that are supposed to produce proteins almost certainly do not for various reasons, either because they do not exhibit any protein coding features, or because the conservation of their reading frames does not support protein coding ability,” said Michael Tress, Researcher, structural computational biology group, CNIO.

According to the findings, more than 90 per cent of human genes produce proteins that originated in metazoans or multicellular organisms of the animal kingdom hundreds of millions of years ago. The figure, however, is over 99 per cent for those genes whose origin pre-dates the emergence of primates 50 million years ago.

“It indicates that the differences between humans and primates at the level of genes and proteins are very small,” researchers noted in a paper published in the journal Human Molecular Genetics.

© TimesOfIndia News



Your Comments (Up to 2000 characters)
Please respect our community and the integrity of its participants. WOC reserves the right to moderate and approve your comment.

Related News

Fuel discovered in old newspapers

  NEW ORLEANS, US: Here’s one way that old-fashioned newsprint beat the Internet: Tulane University scientists have discovered a novel bac ...

Read more
UD chemist investigates reactions that damage paintings

  NEWARK, US: In the days before artists could go to a store and buy commercial paints, they mixed their own, often combining pigments made of l ...

Read more
KBR bags engineering design contract for BP Quad 204 project

  HOUSTON, US: KBR has bagged from Hyundai Heavy Industries Co Ltd contract to perform engineering design and procurement support services for B ...

Read more
Scientifically taking the guilt out of guilty pleasures

BRISBANE, AUSTRALIA: Red wine and chocolate are part of the working week for Australian Institute for Bioengineering and Nanotechnology, Researcher, D ...

Read more
Scientists create natural Alzheimer’s-fighting compound in lab

  NEW HAVEN, US: Scientists at Yale University have developed the first practical method to create a compound called huperzine A in the lab. The ...

Read more
Dow Corning Executive named as Hemlock Semiconductor President

  MIDLAND, US: Hemlock Semiconductor Group named Andrew E Tometich as its new President, effective immediately. Tometich replaces Richard S Door ...

Read more