University Copenhagen Researchers Developed Cleaner, Safer PharmaceuticalsProduction Method

New promising research for cleaner, safer pharmaceuticals

6:15 AM, 17th September 2013
University of Copenhagen Research News
Knud J Jensen, Professor, University of Copenhagen.

COPENHAGEN, DENMARK: A ground-breaking method, developed by chemistry research group at the University of Copenhagen has promised cleaner and safer pharmaceuticals. The research is published in the internationally renowned journal, Chemical Communications, as ‘Site-selective three component reaction for dual functionalization of peptides.’

Knud J Jensen, Professor, University of Copenhagen is convinced that the method will become pivotal in the development of new pharmaceuticals. This method opens a new chest of tools. Jorn B Christensen, Associate Professor, University of Copenhagen have been researching methods for altering proteins and peptides, the chemical structures that run everything in the human body. Jensen asserts that protein drugs are the most rapidly growing group of pharmaceuticals. Protein drugs are used to combat serious illnesses such as sclerosis, leukaemia, diabetes and cancer. However, because their chemical architecture so nearly resembles the body’s own structures, they are tough to work with. Or, rather – they were, said Professor Jensen.

Helpful new substances are traditionally concocted using rather rough methods. The contents of a test tube are typically fed a dash of powerful solvent before being boiled, under high pressure, together with some metal additives to speed along the reaction. Natural compounds like protein based drugs can’t tolerate this, explained Jakob Ewald Rasmussen, a Post Doc in the research group.

Proteins are larger, more intricate and fragile. They have evolved over millions of years to function in water that is: neutral pH, 37 degrees celsius and often without reactive metals, explained Rasmussen and continues - it is under these delicate circumstances that the group has managed to develop new chemistry.

In addition to the delicate approach, the breakthrough method offers two distinct advantages. Firstly, it is a “one-pot” synthesis method. That means that the reactions occur in a single procedure. However, the method also makes it possible to attach two so-called functional groups to an individual protein. The latter sets the group’s research apart and makes the method truly novel.

A functional group can be a coupled molecule, such as polyethylene glycol (PEG). PEG is a compound used in pharmaceuticals to extend the life of a particular drug. But it has a weakness. The compound is a long molecular chain with hard to control contents. If, however, the PEG is divided and then attached to two sites on a protein, the risk of side effects is lowered. Shorter PEG chains can be made cleaner and more uniform. This means that their medicinal effect can be made more predictable and easier to control, explained Knud Jensen.

But the possibility of attaching two functional groups on a single protein also opens the door for entirely new applications. The new chemistry trick makes it possible to synthesize proteins with, not just two, but three functions, because the protein itself can serve a function. This means that proteins can be produced, for example, to target and stick to cancer cells. The two functional groups on a protein can then be used as a contrasting agent, so as to help discern whether a cancer is present through imaging, as well as a luminescent substance, to help guide the surgeon to a tumour’s location when the patient is open and ready to be operated upon, said Jakob E Rasmussen.

Hundreds of biopharmaceutical drugs are already on the market and a peek at the number of biopharm patents reflects huge growth in the area. In 1978, 30 patents were taken out for protein-based pharmaceuticals. That number jumped to 15,600 in 1995 and shot up to 34,527 patent applications in 2001.

© University of Copenhagen News

0 Comments

Login

Your Comments (Up to 2000 characters)
Please respect our community and the integrity of its participants. WOC reserves the right to moderate and approve your comment.

Related News


Curiosity rover completes one Martian year

WASHINGTON DC, US: According to NASA, the space agency’s Mars Curiosity rover completes one Martian year – equivalent to 687 Earth days &n ...

Read more
Bayer, Bion Tech settle patent infringement case in Korea

MONHEIM, GERMANY: Bayer CropScience and Bion Tech, Taiwan, Republic of China, a producer of biological crop protection agents, have settled a patent i ...

Read more
Merck Serono, Mersana to develop antibody-drug conjugates

DARMSTADT, GERMANY: Merck Serono, the biopharmaceutical division of Merck, and Mersana Therapeutics, Inc, announced an agreement to collaborative ...

Read more
Chevron Phillips to construct polyethylene units in Old Ocean, US

THE WOODLANDS, US: Chevron Phillips Chemical Company LP (Chevron Phillips Chemical) held its second groundbreaking ceremony for its US Gulf Coast (USG ...

Read more
Researchers develop molecular computer using sugar

JENA, GERMANY: Researchers at Friedrich Schiller University Jena, Germany have developed the ‘sweetest computer in the world.’ The compute ...

Read more
AkzoNobel to invest in performance coatings business in China

AMSTERDAM, THE NETHERLANDS/SHANGHAI, CHINA: AkzoNobel is investing more than €6.5 million in its Songjiang site near Shanghai to expand an existi ...

Read more