Paracetamol To Cause Liver Failure | Paracetamol Cause Toxic Effects On Liver

Research towards development of safer form of paracetamol

6:11 AM, 12th July 2013
News on paracetamol
Acetaminophen is one of the most widely used drugs for pain and fever reduction.

WASHINGTON DC, US: In an effort to develop a safer form of acetaminophen (paracetamol), researchers have discovered substances that may have less potential toxic effects on the liver. Acetaminophen is one of the most widely used drugs for pain and fever reduction. A report on the research appears in ACS Medicinal Chemistry Letters.

Researcher Roman Shchepin and colleagues explained that a link exists between acetaminophen and liver damage. The damage may be severe and can occur with intentional and accidental overdoses, as well as when susceptible individuals take the drug. Indeed, acetaminophen has been implicated in almost 50 per cent of all acute liver failure cases in the United States alone. Scientists have known the biochemical basis of acetaminophen’s liver toxicity, and Shchepin and colleagues set out to develop safer versions of acetaminophen.

They described the design and testing of two compounds that have a similar architecture to acetaminophen, but aren’t toxic to liver cells grown in the laboratory. The researchers said that, although further testing is needed, these compounds are promising candidates for acetaminophen replacements.

© Worldofchemicals News provides you the best chemical research news, chemical and engineering news, chemistry research news,



Your Comments (Up to 2000 characters)
Please respect our community and the integrity of its participants. WOC reserves the right to moderate and approve your comment.

Related News

Axiall searches for new CEO, looks to improve financial performance

ATLANTA, US: Axiall Corporation said its president and CEO Paul Carrico has retired, effective immediately. Axiall is now searching for a new CEO as i ...

Read more
Scientists develop better way to screen chemicals for cancer-causing effects

BERKELEY, US:  The vast majority of the thousands of chemicals in our homes and workplaces have not been tested to determine if they cause cancer ...

Read more
Orange is the new red

BERKELEY, US: Overexposure to sunlight, which is damaging to natural photosynthetic systems of green plants and cyanobacteria, is also expected to be ...

Read more
Graphene flexes its electronic muscles

HOUSTON, US: Flexing graphene may be the most basic way to control its electrical properties, according to calculations by theoretical physicists at R ...

Read more
Engineering atoms inside the jet engine: the Great British Take Off

CAMBRIDGE, US: The Periodic Table may not sound like a list of ingredients but, for a group of materials scientists, it’s the starting point for ...

Read more
10-year old Daniel Liu wins national “You Be the Chemist” competition

OTTAWA HILLS, US: Ottawa Hills student Daniel Liu captured the National “You Be the Chemist” competition on 22 June at the Kimmel Center f ...

Read more uses cookies to ensure that we give you the best experience on our website. By using this site, you agree to our Privacy Policy and our Terms of Use. X