Paracetamol To Cause Liver Failure | Paracetamol Cause Toxic Effects On Liver

Research towards development of safer form of paracetamol

6:11 AM, 12th July 2013
News on paracetamol
Acetaminophen is one of the most widely used drugs for pain and fever reduction.

WASHINGTON DC, US: In an effort to develop a safer form of acetaminophen (paracetamol), researchers have discovered substances that may have less potential toxic effects on the liver. Acetaminophen is one of the most widely used drugs for pain and fever reduction. A report on the research appears in ACS Medicinal Chemistry Letters.

Researcher Roman Shchepin and colleagues explained that a link exists between acetaminophen and liver damage. The damage may be severe and can occur with intentional and accidental overdoses, as well as when susceptible individuals take the drug. Indeed, acetaminophen has been implicated in almost 50 per cent of all acute liver failure cases in the United States alone. Scientists have known the biochemical basis of acetaminophen’s liver toxicity, and Shchepin and colleagues set out to develop safer versions of acetaminophen.

They described the design and testing of two compounds that have a similar architecture to acetaminophen, but aren’t toxic to liver cells grown in the laboratory. The researchers said that, although further testing is needed, these compounds are promising candidates for acetaminophen replacements.

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