caffeine along with gold new compounds may kill cancer cells without hurting other cells

Caffeine mixed with gold may kill cancer cells, finds new study

10:08 AM, 28th February 2014
caffeine-based gold compounds may kill cancer cells
According to a new research, a caffeine-based compound with a small amount of gold could someday be used as an anticancer agent.

WASHINGTON DC, US: Ingesting too much of caffeine has many side effects - restlessness, increased heart rate, having trouble sleeping. A recent research has shown that the stimulant also has a good side, it can kill cancer cells. Now, researchers report in the ACS journal Inorganic Chemistry that combining a caffeine-based compound with a small amount of gold could someday be used as an anticancer agent.

Researchers Angela Casini, Michel Picquet and colleagues noted that caffeine and certain caffeine-based compounds have recently been in the spotlight as possible anticancer treatments. But drinking gallons of coffee, sodas and energy drinks isn’t the solution. And the regular caffeine in these drinks would start to have negative effects on healthy cells, too, at the levels necessary to kill cancerous ones. Gold also can wipe out cancer cells, but, like caffeine, it can harm healthy cells. So, the research team put the two together into certain configurations to see whether the new caffeine-based gold compounds could selectively stop cancer cells from growing without hurting other cells.

They made a series of seven new compounds, called caffeine-based gold (I) N-heterocyclic carbenes, in the laboratory and studied them. The scientists found that, at certain concentrations, one of the compounds of the series selectively killed human ovarian cancer cells without harming healthy cells. In addition, the compound targeted a type of DNA architecture, called “G-quadruplex,” that is associated with cancer.

© American Chemical Society News

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