Regular exercise reduce heart risks improves heart cells mitochondria

Exercise to keep heart healthy, targets heart cells’ mitochondria

10:57 AM, 17th February 2014
Research on  heart cells mitochondria
Researchers are reporting moderate, long-term physical activity appears to improve cardiovascular health in mice by targeting the heart cells’ powerhouses - the mitochondria.

WASHINGTON DC, US: Exercise has many benefits, whether lifting weights in a gym or just walking around the block, it helps people lose weight and build stronger muscles. Some studies suggest that it may reduce the risk of developing cancer and other diseases. Researchers now report in ACS’ Journal of Proteome Research that moderate, long-term physical activity appears to improve cardiovascular health in mice by targeting the heart cells’ powerhouses - the mitochondria.

Researchers Eduard Sabido, Francisco Amado and colleagues explained that despite the well-documented benefits of exercise, the exact way that it helps the heart is not well understood. Sure, it helps strengthen the heart muscle so it can pump more blood throughout the body more efficiently. And people who get off the couch and exercise regularly have a reduced risk of developing heart problems and cardiovascular disease. One estimate even claims that 250,000 deaths every year in the US are at least partially due to a lack of exercise. But how this all happens in the body at the molecular level has perplexed researchers - until now.

The team found that laboratory mice (stand-ins for humans) that exercised for 54 weeks on a treadmill-running regimen had higher levels of certain proteins in the mitochondria of their heart cells than mice that did not exercise. Mitochondria produce energy for the body’s cells. In particular, they identified two proteins, kinases called RAF and p38, that seem to trigger the beneficial cardiovascular effects of lifelong exercise training, said the researchers.

 

© American Chemical Society News

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