Inorganic biomaterials soft-tissue adhesion

Inorganic biomaterials for soft-tissue adhesion

6:09 AM, 30th August 2017
Inorganic biomaterials for soft-tissue adhesion
Dispersions containing hydroxyapatite (HAp) nanoparticles, dried and made into plates have outstanding adhesive properties, and are biocompatible and biodegradable.

Researchers at Okayama University describe in Acta Biomaterialia a new type of biocompatible adhesive material. The adhesive, made from nanoparticles of hydroxyapatite, glues both synthetic hydrogels and mouse soft tissue, providing a promising alternative to organic materials currently in use for clinical applications.

As an alternative to surgical stitching with suture, the practice of using adhesive organic materials for joining soft tissue has been around for decades. However, the currently used clinical adhesives often suffer from limited biocompatibility and/or sub-optimal adhesive strength. A team of researchers led by Takuya Matsumoto from Okayama University and colleagues has now identified a class of biocompatible–biodegradable compounds showing promising adhesion properties when applied to mouse soft tissues.

The scientists relied on the recent discovery that certain nanostructured materials display remarkable adhesiveness. For example, introducing a dispersion of silicon oxide nanoparticles between two hydrogels results in rapid adhesion of the hydrogels — an effect now developed further for industrial, non-clinical applications. In order to achieve the level of biocompatibility required for clinical usage, Matsumoto and colleagues experimented with nanoparticles of hydroxyapatite (HAp), an inorganic material found in human hard tissues such as bones and teeth. HAp-composites are routinely used for orthopedic and dental implants, as well as in tissue engineering. The researchers reckoned that dispersions of nanoparticulate HAp should behave as biocompatible adhesives — an idea they were able to confirm experimentally.

Matsumoto and colleagues first examined the effect of HAp-nanoparticle dispersions on the adhesion of synthetic hydrogels; the presence of HAp clearly enhanced the level of adhesion. Drying the dispersions — resulting in solid HAp ‘plates’ — increased the cohesion between the HAp nanoparticles, and using the plates as the adhesive agent then led to even better inter-hydrogel adhesion. The scientists then tested the HAp plates on different mouse soft tissues: muscle, lung, kidney and other tissues could be successfully glued together. An adhesion strength at least twice as large as obtained with a commercial organic glue was observed for mouse skin tissues.

The findings of Matsumoto and colleagues are not only relevant for developing new procedures for surgical-wound healing, but also for drug-delivery technologies — the potential of hydrogels as drug containers have long been recognized. In the words of the researchers: “Our results will help not only in developing an efficient approach to close incised soft tissues but also in finding novel ways to integrate soft tissues with synthetic hydrogels (such as drug reservoirs).”

© Okayama University

 

See the News in Chemical Today magazine

https://www.worldofchemicals.com/digitalissue/chemical-today-august-2017/22

View the magazine on Mobile, download the Chemical Today magazine app

http://bit.ly/21W5H0z

http://apple.co/1ZwID77

0 Comments

Login

Your Comments (Up to 2000 characters)
Please respect our community and the integrity of its participants. WOC reserves the right to moderate and approve your comment.

Related News


Improved sustainable method to refine metals

A team of chemists in Canada has developed a way to process metals without using toxic solvents and reagents. The system, which also consumes far less ...

Read more
Bio-based paraxylene in bioplastics PET bottles to create new opportunities

Paraxylene, also known as PX or P-Xylene, is an aromatic hydrocarbon compound, derived particularly from benzene. Paraxylene is a colourless, toxic, s ...

Read more
New eco-friendly coating for boats from shellfish waste

Researchers from the GREEN-CHEM network at Ghent University have developed a new coating for boats based on the recycled waste from shellfish. The cla ...

Read more
Industrial adhesives to expand moderately in volume terms

Global Industrial Adhesives Market size is expected to expand at moderate growth rate in terms of volume during the forecast period. Healthy growth of ...

Read more
IIOT: More an investment than an expense

In an interview, Vivek Gupta, General Manager & Head Instrument, DCM Shriram Ltd with Chemical Today Magazine talks about IIOT in the process indu ...

Read more
Enhancing safety, cost-effectiveness in high precision component cleaning

Hymatic Engineering Coy Ltd, part of Honeywell Aerospace, based in Redditch in the UK, specialises in the design, development and manufacture of cryog ...

Read more
www.worldofchemicals.com uses cookies to ensure that we give you the best experience on our website. By using this site, you agree to our Privacy Policy and our Terms of Use. X