Logic behind tongue-twisting generic names drugs

Logic behind tongue-twisting generic names of drugs

11:10 PM, 24th January 2012
Logic behind tongue-twisting generic names of drugs
Logic behind tongue-twisting generic names of drugs.

OHIO, US: The logic behind the odd-sounding generic names of drugs is published in Chemical & Engineering News (C&EN), newsmagazine of the American Chemical Society, the world’s largest scientific society. Carmen Drahl, Associate Editor, C&EN explained that until 1961 there was no standard for assigning drugs generic names, which are different from brand names like Tamiflu (oseltamivir), Nexium (esomeprazole) and Herceptin (trastuzumab).

Three medical organizations created the US adopted names (USAN) council to assign simplified alternatives to the unwieldy proper names the International Union of Pure & Applied Chemistry gives to molecules. For instance, under USAN’s guidance, ‘cis-8-methyl-N-vanillyl-6-nonenamide’ becomes ‘zucapsaicin.’ The council recommends generic names to an international agency of the World Health Organization. The tongue-twisting words the USAN council creates are products of ‘stems’ that describe a drug’s characteristics, which Drahl likens to the Latin and Greek roots of many English words.

Drahl wrote that these stems describe everything from a drugs’ function to its shape. For instance, the “-prazole” ending of Nexium’s generic name, esomeprazole, reveals that it is a type of antiulcer medication. Similar drugs will have the same stems in their names, allowing those familiar with the stems to crack the code. The USAN council is careful to avoid words that are difficult to pronounce in foreign languages or that may have other meanings abroad.

© American Chemical Society News

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