Lonza forms development manufacturing agreement with Genmab

Lonza forms development and manufacturing agreement with Genmab

11:40 PM, 24th October 2011
Lonza forms development and manufacturing agreement with Genmab
Stephan Kutzer, COO, Lonza Custom Manufacturing.


BASEL, SWITZERLAND: Lonza forms a new development and manufacturing agreement with Genmab A/S. This agreement secures a development and cGMP manufacturing plan for Genmab to produce a novel ADC product targeting tissue factor (TF). Financial details of the agreement were undisclosed.

The use of ADCs as therapeutic agents is becoming an important therapeutic approach for the treatment of various cancers. This project utilizes Lonza’s experts in both antibody production and drug conjugation, providing a harmonized solution for Genmab’s technology.

Lonza will initiate process development and cGMP manufacturing for Genmab’s monoclonal antibody HuMax-TF in its Slough, UK facility. This antibody has been expressed by Genmab A/S in Lonza’s GS Gene Expression System. The naked antibody will be conjugated by Lonza at its ADC plant in Visp, CH to a cytotoxic drug in order to form the antibody drug conjugate HuMax-TF.

“The agreement with Genmab A/S on this novel product leverages Lonza’s experience in both high potency synthetic chemistry and mammalian biopharmaceutical manufacturing. Lonza is uniquely positioned to offer complete development and manufacturing services for the production of antibody drug conjugates like HuMax-TF ADC,” said Stephan Kutzer, COO, Lonza Custom Manufacturing.

(C) WOC News




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