Mesoporous particles used in drug delivery system safe human bodies

Mesoporous particles used in drug delivery system safe for human bodies

11:28 AM, 21st May 2015
Mesoporous particles used in drug delivery system safe for human bodies
Fig 1 External views of porous phospholipid particles (a, b) Particles created in organic (non-aqueous) solvent (c, d) particles created in organic solvent in the presence of small amount of water. The shape of the particles varies depending on the presence/absence of water in the solvent. © NIMS

IBARAKI, JAPAN: A research group has succeeded in developing porous particles (mesoporous particles) consisting solely of phospholipids, a biological component that is suitable for use as a drug delivery system.

The research group led by MANA scientist Kohsaku Kawakami, postdoctoral researcher Shaoling Zhang and MANA principal investigator Katsuhiko Ariga, at the International Center for Materials Nanoarchitectonics (MANA), NIMS (Sukekatsu Ushioda, president) discovered mesoporous materials to be capable of serving as a drug delivery system. 

Also the study published in the ‘Journal of Physical Chemistry C’ issued by the American Chemical Society mentioned that in conventional studies, hard materials such as silica and carbon materials have been used for such purposes, posing safety concerns to patients. The mesoporous material developed in this study consists exclusively of biologically-derived materials and is therefore expected to be very safe for humans.

Acquisition of official approval is one of the hurdles in the development of materials for use as a drug delivery system. However, the phospholipids examined in this study have already been used as emulsions and liposomes, and thus are not regarded as new additives. This fact is a great advantage of this material in view of commercialization.

This material comprises highly uniform mesoporous particles and has features for it to be used as a powder inhalation carrier. Since this material consists of lipid bilayer membranes that are similar to biological membranes, it possesses the characteristics of both mesoporous particles and liposomes. For example, it can be used with both hydrophobic and hydrophilic drugs.

Hydrophobic drugs can be embedded in a lipid bilayer membrane, and hydrophilic drugs can be inserted into hydrophilic regions between lipid bilayer membranes. Furthermore, as it is also feasible for the material to hold drugs in its mesopores, the material is capable of carrying drugs with various physical properties. Since phospholipids can be easily modified, it is conceivable that various kinds of surface modifications can be applied to the material.

This material is suited for industrial production as it can be easily prepared through freeze-drying. And it is expected to be useful as a drug carrier assuming any administration route and as a cosmetic ingredient. The unique shape of the particles also may add value to the commercial product.

© National Institute for Materials Science (NIMS) News



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