Georgia University researchers developed new chemotherapy drug kill cancer cells effectively
X
Waste Management Expo 2020 MAR 12&13 BIEC, Bengaluru, India

New formulation of chemotherapy drug to kill cancer cells effectively

9:56 AM, 8th July 2014
University of Georgia research on killing cancer cells
Shanta Dhar, Assistant Professor, University of Georgia.

GEORGIA, US: University of Georgia researchers have developed a new formulation of cisplatin, a common chemotherapy drug that significantly increases the drug’s ability to target and destroy cancerous cells. Cisplatin may be used to treat a variety of cancers, but it is most commonly prescribed for cancer of the bladder, ovaries, cervix, testicles and lung. It is an effective drug, but many cancerous cells develop resistance to the treatment.

Shanta Dhar, Assistant Professor, UGA Franklin College of Arts and Sciences, and Rakesh Pathak, a postdoctoral researcher in Dhar’s lab, constructed a modified version of cisplatin called Platin-M, which is designed to overcome this resistance by attacking mitochondria within cancerous cells. They published their findings recently in the Proceedings of the National Academy of Sciences.

“You can think of mitochondria as a kind of powerhouse for the cell, generating the energy it needs to grow and reproduce. This prodrug delivers cisplatin directly to the mitochondria in cancerous cells. Without that essential powerhouse, the cell cannot survive,” said Dhar.

Sean Marrache, a graduate student in Dhar’s lab, entrapped Platin-M in a specially designed nanoparticle 1,000 times finer than a human hair that seeks out the mitochondria and releases the drug. Once inside, Platin-M interferes with the mitochondria’s DNA, triggering cell death.

Dhar’s research team tested Platin-M on neuroblastoma-a cancer commonly diagnosed in children-that typically originates in the adrenal glands. In preliminary experiments using a cisplatin-resistant cell culture, Platin-M nanoparticles were 17 times more active than cisplatin alone.

“This technique could become a treatment for a number of cancers, but it may prove most useful for more aggressive forms of cancer that are resistant to current therapies,” said Pathak.

Both Dhar and Pathak caution that their experimental results are preliminary and they must do more work before Platin-M enters any clinical trials. However, their early results in mouse models are promising, and they are currently developing safety trials in larger animals.

“Cisplatin is a well-studied chemotherapy, so we hope our unique formulation willenhance its efficacy. We are excited about these early results, which look very promising,” said Dhar.

© University of Georgia News

0 Comments

Login

Your Comments (Up to 2000 characters)
Please respect our community and the integrity of its participants. WOC reserves the right to moderate and approve your comment.

Related News


AkzoNobel to sell paper chemicals business to Kemira for €153 million

AMSTERDAM, THE NETHERLANDS: AkzoNobel announced the intended sale of its global paper chemicals business to Kemira for €153 million. Paper Chemic ...

Read more
19,000 protein producing genes in humans, finds new study

LONDON, UK: In a new research, scientists have found the number of protein generating genes in humans to be 19,000 - 1,700 fewer than the most recent ...

Read more
New laser technology to identify chemical hazards

EDINBURGH, UK: A portable laser device is being developed at Heriot-Watt that can instantly identify chemical hazards, increasing the safety of emerge ...

Read more
ADM to acquire WILD Flavors

DECATUR, US: Archer Daniels Midland Company (ADM) is acquiring WILD Flavors GmbH, giving ADM the ability to offer food and beverage companies a compre ...

Read more
Squid’s teeth may find use in reconstructive surgery

WASHINGTON DC, US: Tentacles of squid are loaded with hundreds of suction cups, or suckers, and each sucker has a ring of razor-sharp “teeth&rdq ...

Read more
Arkema, Omya sign distribution agreement in Europe

COLOMBES, FRANCE/OFTRINGEN, SWITZERLAND: Omya, a leading global provider and distributor of specialty chemicals, and Arkema, a leading global chemical ...

Read more
www.worldofchemicals.com uses cookies to ensure that we give you the best experience on our website. By using this site, you agree to our Privacy Policy and our Terms of Use. X