University Of Minnesota Researchers Developed Antidote For Cyanide Poisoning

Promising antidote for cyanide poisoning discovered

5:00 AM, 2nd February 2013
University Of Minnesota Research News
Scientists have discovered a substance that could be used to create a better antidote for cyanide poisoning by terrorists.

WASHINGTON DC, US: In an advance toward closing a major gap in defenses against terrorist attacks and other mass casualty events, scientists are reporting discovery of a promising substance that could be the basis for development of a better antidote for cyanide poisoning. Their report, which describes a potential antidote that could be self-administered, much like the medication delivered by allergy injection pens, appears in ACS’ Journal of Medicinal Chemistry.

Steven E Patterson and colleagues at the University of Minnesota Centre for Drug Design explained that the only existing antidotes for cyanide, recognized as a high-risk substance for potential use by terrorists, must be administered by intravenous infusion. That procedure requires highly trained paramedical personnel and takes time. Cyanide, however, is a fast-acting poison. In a situation involving mass casualties, only a limited number of victims could be saved. Patterson’s team thus sought an antidote that could be administered by intra-muscular (IM) injection, a simpler procedure that could be administered rapidly to a large number of victims or even be self-administered.

Their report describes discovery of a substance, sulfanegen TEA, “which should be amenable for development as an IM injectable antidote suitable for treatment of cyanide victims in a mass casualty setting. Further development, including efficacy in lethal cyanide animal models, will be reported at a later date.”

© American Chemical Society News



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