Self-assembling material could lead artificial arteries

Self-assembling material could lead to artificial arteries

11:37 AM, 29th September 2015
Self-assembling material could lead to artificial arteries
A new method uses peptide and protein molecules that can self-assemble and be guided to grow into complex shapes.

LONDON, UK: The study, which will appear in the journal Nature Chemistry, describes how peptides and proteins can be used to create materials that exhibit dynamic behaviours found in biological tissues like growth, morphogenesis, and healing.

The method uses solutions of peptide and protein molecules that, upon touching each other, self-assemble to form a dynamic tissue at the point at which they meet. As the material assembles itself it can be easily guided to grow into complex shapes.

This discovery could lead to the engineering of tissues like veins, arteries, or even the blood-brain barrier, which would allow scientists to study diseases such as alzheimer’s with a high level of similarity to the real tissue, which is currently impossible. The technique could also contribute to the creation of better implants, complex tissues, or more effective drug screening methods.

“What is most exciting about this discovery is the possibility for us to use peptides and proteins as building-blocks of materials with the capacity to controllably grow or change shape, solely by self-assembly,” said Alvaro Mata, director, Institute of Bioengineering at QMUL and lead author of the paper.

“The system is dynamic so it can be triggered on demand to enable self-assembly with a high degree of control, which allows the creation of complex shapes with a structure that resembles elements of native tissue,” said Karla Inostroza-Brito, PhD student and first author of the paper.

© Queen Mary University of London News

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