Boston College Researchers Designed Single Proton Catalyst

Sustainable, highly efficient catalysts developed by charge of a single proton

9:34 AM, 18th February 2013
Boston College Research News
Amir Hoveyda, Professor, Boston College.

BOSTON, US: Chemists at Boston College have designed a new class of catalysts triggered by the charge of a single proton. The simple organic molecules offer a sustainable and highly efficient platform for chemical reactions that produce sets of molecules crucial to advances in medicine and the life sciences.

Unearthing a reliable, truly general, efficient synthesis of single mirror-image isomers has proven elusive. Previous methods suffer from a combination of extreme temperatures, long reaction times, limited scope, low selectivity, the need for rare or precious metals and highly toxic elements.

The new catalysts are small organic molecules derived from the abundant and renewable amino acid valine and can be synthesized in four steps through the use of commercially available and inexpensive materials, according to Amir Hoveyda, Professor, Boston College.

The catalyst, used in as little as one quarter of a per cent, promotes reactions that are complete within two minutes to four hours typically at room temperature, according to the co-authors, Marc Snapper, Professor, Boston College; Fredrik Haeffner, Senior Research Associate; Post-doctoral researchers Sebastian Torker and Tatiana Pilyugina, and Graduate Students Erika Vieira and Daniel Silverio.

Products formed consist mainly of a single mirror-image isomer of a large assortment of amines and alcohols, which serve as building blocks for the preparation of molecules capable of advancing new drug therapies relevant to human healthcare.

The electronic activation sparked by the proton and internal hydrogen bonds play a key role in every stage during catalysis of the carbon-carbon bond forming process, according to the researchers. This includes achieving high enantioselectivities - favouring one mirror-image isomer - as well as unprecedented rates of catalyst regeneration and product release.

“A reaction that can be initiated by a minute amount of a readily accessible and inexpensive catalyst to afford valuable organic molecules with high selectivity and which requires only renewable resources, as opposed to precious and rare elements, is extremely important to future advances in medicine and the life sciences,” said Hoveyda.

Efficient, selective, cost-effective and sustainable protocols for preparation of organic molecules offer realistic access to significant quantities of a range of biologically active entities. Enantioselective synthesis, preparation of one mirror-image isomer, is crucial in this regard since most important entities in biology and medicine have the property of being handed as well.

“Chemical transformations that are highly selective as well as economical are very important for both discovery and commercial development of new therapeutic and diagnostic agents,” said Robert Lees, National Institutes of Health’s National Institute of General Medical Sciences.

The small-molecule catalysts initiate reactions of readily available boron-containing reagents with easily accessible imines and carbonyls, producing amines and alcohols with a high degree of enantiomeric purity. The catalyst’s ability to provide access to these prized enantiomerically enriched organic compounds in a manner that is not only efficient and selective but also economical and sustainable for the long term, will be of enormous value to researchers developing anti-cancer agents, therapeutics that reverse multi-drug resistance or anti-viral drugs.

“The new catalysts have all the key characteristics of a class of molecules that can serve as a blueprint for the invention of many additional important and useful reaction promoters in the future,” said Hoveyda.

© Boston College News

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