Soon normal Insulin will be replaced by Insulin pills save millions frompain daily shots

Towards development of insulin pills

9:01 AM, 20th December 2013
Insulin pills in market
Scientists report new progress on a long-sought insulin pill that could save millions from the pain of daily shots.

WASHINGTON DC, US: Discovery of Insulin has saved the life of many people around the world. Now scientists are reporting a new development toward a long-sought insulin pill that could save millions from the pain of daily shots. This advancement could someday not only eliminate the pain, but also get needle-wary patients to take their medicine when they should. The report is published in ACS journal Biomacromolecules.

Researcher Sanyog Jain and colleagues explained that patients with diabetes sometimes skip doses or stop taking their insulin because the injections can be painful. But doing so puts their health in danger. An estimated 347 million people globally are living with diabetes. In the US, more than a quarter of these patients are taking some kind of insulin therapy. For years, researchers have sought a way to transform delivery of this therapy from a shot to a pill, but it has been a challenge. The body’s digestive enzymes that are so good at breaking down food also break down insulin before it can get to work. In addition, insulin doesn’t get easily absorbed through the gut into the bloodstream. To overcome these hurdles, Jain’s team combined two approaches to shield insulin from the digestive enzymes and then get it into the blood.

They packaged insulin in tiny sacs made of lipids, or fats, called liposomes, which are already used in some treatments. Then, they wrapped the liposomes in layers of protective molecules called polyelectrolytes. To help these “layersomes” get absorbed into the bloodstream, they attached folic acid, a kind of vitamin B that has been shown to help transport liposomes across the intestinal wall into the blood. In rats, the delivery system lowered blood glucose levels almost as much as injected insulin, though the effects of the layersomes lasted longer than that of injected insulin.

© American Chemical Society News 

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